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KMID : 0616120080390020118
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Korean Journal of Pharmacognosy
2008 Volume.39 No. 2 p.118 ~ p.122
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Effect of Betulinic Acid Isolated from Ziziphus jujuba Lam on Infection of Rotavirus in MA-104 Cell
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Lee Keyong-Ho
Rhee Ki-Hyeong
Cho Choa-Hyung
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Abstract
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This study was conducted to evaluate the inhibitory effects of betulinic acid isolated from Ziziphus jujuba on various human rotavirus, such as KU, S2 and YO. The results obtained are summarized as follows: At the concentration of betulinic acid 0.1/2%, all human rotavirus is showed a maximum effect on their growth even though it’s evaluated on the in vitro test. The each inhibitory rate of MA-104 cells infected by human rotavirus KU, S2 and YO was 62.1%, 59.7% and 65.2%, respectively, at the concentration of 0.1/2%. The anti-virus activity of betulinic acid was showed as the dose-dependent manner at the used dosages except at the dose of 0.1%.
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KEYWORD
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Ziziphus jujuba, Betulinic acid, Rotavirus
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